Hello. Thanks for welcoming me and my non-Vizsla!
Here's the first update... £500 later, anti-inflammatories and antibiotics have made no difference. If anything, the skin seems a tiny bit tighter over the lump. My dog is absolutely well and bright, not experiencing any pain or irritation, and doesn't seem bothered at all that he is turning into a rhinoceros! So I'm not too worried about him for the moment. I just want to deal with it before it turns into something more serious.
Fine needle aspirates were sent by the local vet to a lab for cytological investigation.
This email is from one vet at the local practice -
"We have results back from the lab - they've informed us that your dog has a pyogranulomatous inflammation. To you and me, that means he has a site of inflammation with some pus and a small amount of blood in. The plan going forward now depends on how he is responding. If he's doing well, and the swelling is going down with the antibiotics then I think we need to continue the medication and re-check Pip in a week's time. If he isn't responding at all the to the medication and the swelling is the same size or larger, then we should have him back in to aspirate the mass for culture."
I looked up pyogranulomatous inflammation and found this info:
Pyogranulomatous (Chronic Active) InflammationThese preparations have an inflammatory population that contains both neutrophils and a prominent fraction of macrophages (15% to 50% macrophages). Multinucleated giant cells, reactive fibroblasts, and lymphocytes may be present also. Pyogranulomatous inflammation suggests a cause other than “routine” bacterial infection. Fungal infections (e.g., blastomycosis), higher bacteria (e.g., Actinomyces), mycobacteria, protozoa, and noninfectious disorders (e.g., foreign bodies, necrosis) are common causes of pyogranulomatous inflammation. - https://www.vetfolio.com/learn/article/cytology-of-inflammation
I asked a few basic questions in reply. Then the more senior vet at the same local practice replied with this: "Next week is better as we want more time with the current medication. If the lump isn’t resolving with the current antibiotics; we may need to try to aspirate for culture. The lump was pretty solid and did not yield any liquid the other day. The procedure the other day involved removal of some cells for cytology. Culture involves trying to get some material out of the lump that is sent in a swab to the lab where they grow and identify any bacteria and then give us a sensitivity panel which lets us know which antibiotics to use. We do this when we are not making enough progress with broad spectrum antibiotics."
So now at least I can have a weekend off before I have to do anything. But I am confused - 1. if it's pyogranulomatous inflammation and this suggests a cause other than normal bacteria, it's no wonder the broad spectrum antibiotics are doing nothing, so why are we waiting/continuing them? 2. if the lump is solid and doesn't yield liquid, are we actually dealing with an infection? 3. If it is an infection, pyogranulomatous inflammation suggests that it isn't straightforward bacterial, so I hope the panel will be testing for other types of infection, 4. how would an infection have got in there, since there was never any cut/splinter etc., 5. So far, it is all in line with the dermoid cyst, but has the vet actually read anything I sent? Done her own research? 6. Why isn't she interested in the nasal pit?
So I will be asking all these questions of the vet.
I investigated getting a second opinion from the RCVS clinic, but they are not providing second opinions at the moment because COVID has/is causing a backlog of cases (bloody lockdown puppy purchasers.....!).
What I'm tempted to do is ask for a direct referral now to the RCVS Hospital (not too far from London) and combine a CT/MRI scan with the aspiration for culture. That way, he would only be having one further general anaesthetic instead of 2+. And the imaging would be able to give a broader picture of what's going on.
Thanks for keeping me company on this lonely and expensive journey... I'll try to continue updates. If long and detailed isn't your thing, then bad luck!
If anyone else with a dog diagnosed with a nasal dermoid sinus / cyst issue has any info on the diagnostic process and whether any of this overlaps, please do share.
AJBB